Effects of Moderate-intensity Interval Aerobic Exercise (MIIAE) on Inflammatory, Immune, Metabolic, Physical Fitness, and Quality of Life Parameters in Breast Cancer Patients Undergoing Radiotherapy.
Starting soon · Not applicable
Conditions studied: Radiotherapy, Inflamation, Immune System, Physical Fitness, Breast Cancer
In brief
Breast cancer and its treatment with radiotherapy may be associated with systemic inflammatory, hematological, cardiac, body composition, functional and quality-of-life alterations. Exercise has emerged as a non-pharmacological strategy with potential benefits during oncological treatment; however, further evidence is needed regarding the effects of supervised moderate-intensity interval aerobic exercise during radiotherapy. This randomized controlled trial aims to evaluate the effects of a supervised moderate-intensity interval aerobic exercise programme on systemic inflammatory and immune-derived hematological indices, cardiac biomarkers, body composition, muscle strength, lower-limb power, sleep quality and breast cancer-specific quality of life in women with breast cancer undergoing radiotherapy. Participants will be allocated to either an experimental group performing supervised moderate-intensity interval aerobic exercise during radiotherapy or to a control group receiving usual care without structured exercise during the study period. Outcomes will be assessed at baseline and after completion of the intervention period.
Key facts
- Study ID
- NCT07583719
- Run by
- Universidad Francisco de Vitoria
- People needed
- 40
- Starts
- 2026-06-01
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-05-13
Who can join
Age: 20 and older, up to 65. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Women aged between 20 and 65 years.
- Clinical diagnosis of breast cancer (Stage I-III).
- Patients who have undergone lumpectomy or mastectomy.
- Scheduled to start radiotherapy treatment.
- Sedentary lifestyle according to international physical activity guidelines.
- Ability to understand and follow instructions.
- Ability to provide written informed consent.
You may not qualify if…
- Presence of infectious disease.
- Cardiovascular or respiratory disease.
- Metastatic disease.
- Uncontrolled diabetes mellitus.
- Neuropathy.
- Physically active individuals meeting WHO physical activity recommendations.
- Participation in an exercise intervention program within the last 3 months.
- Any condition that, in the opinion of the research team, may compromise safety or participation.
Full record on ClinicalTrials.gov
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