Spasticity in SCI Following Acute Intermittent Hypoxia

Recruiting now · Not applicable

Conditions studied: Spinal Cord Injuries (SCI)

In brief

This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.

Key facts

Study ID

NCT07583498

Run by

Zev Rymer

People needed

10

Starts

2026-03-17

Expected to finish

2028-03-01

Last updated by the study team

2026-05-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age >= 18
• Non-progressive spinal Cord injury at least 6 months prior
• Level of injury between C1-C8
• ISNCSCI ASIA classification C or D
• Measurable Spasticity

You may not qualify if…

• Pre-existing hypoxic pulmonary disease
• Positive Covid-Pneumonia diagnosis within 1 year of visit
• Uncontrolled hypertension >140/90 mmHg
• Individuals who are currently pregnant/nursing or planning on becoming pregnant
• Individuals with a tracheostomy or who utilize mechanical ventilation
• A botulinum toxin injection to upper extremity musculature within the past 3 months
• Currently taking Baclofen
• Congestive Heart Failure
• Cardiac arrhythmias
• Uncontrolled diabetes mellitus
• Chronic obstructive pulmonary disease
• Emphysema
• Severe Asthma
• Previous myocardial infarction
• Carotid/intracerebral artery stenosis
• Orthopedic injuries or surgeries that impact the ability to use the upper extremity
• History of Epilepsy

Where it is running

• Shirley Ryan AbilityLab — Chicago, Illinois, United States (enrolling)

Full record on ClinicalTrials.gov

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