Evaluating RELiZORB Use for the Treatment of Feeding Intolerance in Adults With Moderate to Severe Acute Pancreatitis

Enrolling by invitation · Phase 4

Conditions studied: Acute Pancreatitis (AP), Enhancing Enteral Nutrition Tolerance

In brief

The goal of this study is to learn if Relizorb, a fat-digesting enzyme, can improve tolerance of tube feeds in adult patients with moderate to severe pancreatitis. The main question it aims to answer is: Does Relizorb allow more nutrition to be delivered to participants than they received without it? Participants will be observed with standard, universal monitoring after adding Relizorb to their nutrition regimen.

Key facts

Study ID

NCT07583342

Run by

Northwell Health

People needed

15

Starts

2025-12-08

Expected to finish

2026-12-01

Last updated by the study team

2026-05-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female aged 18 + years of age
• Admission to the Surgical Intensive Care Unit in the Northwell Health hospital system
• Moderate to severe acute pancreatitis based on Atlanta criteria
• Inability to tolerate ≥75% of goal EN (25 kcal/kg/d)

You may not qualify if…

• Moribund patients expected to expire within 120 hours
• Evidence of unresolved intestinal obstruction, ischemia, bleeding, perforation, fistulas or tract discontinuity, or other contraindication for enteral nutrition
• Diagnosis or evidence of C. Difficile or other gastrointestinal infection that may manifest with diarrhea
• Pre-existing constipation defined as laxative or stool softener use prior to admission to the hospital
• Patients receiving cancer-related treatment in the last 3 months
• History of cystic fibrosis
• Any other reason that the treating or investigator team considers to be a contraindication to enteral nutrition

Where it is running

• South Shore University Hospital — Bay Shore, New York, United States
• North Shore University Hospital — Manhasset, New York, United States
• Lenox Hill Hospital — Manhattan, New York, United States
• Long Island Jewish Medical Center — New Hyde Park, New York, United States
• Staten Island University Hospital — Staten Island, New York, United States

Full record on ClinicalTrials.gov

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