CVFs in SIH: EID vs. PCD CTM

Recruiting now · Not applicable

Conditions studied: Spontaneous Intracranial Hypotension

In brief

The purpose of this research study is to compare two types of Computed Tomography Myelography (CTM) scans, one on the photon counting detector scanner (called PCD-CTM) and the other on the energy integrating detector scanner (called EID-CTM); both of which doctors usually use to diagnose abnormal connections between the cerebrospinal fluid and the venous system, or CSF-venous fistulas. This study will help to see if the newer PCD-CTM scan can find more spinal fluid leaks \[CSF-venous fistulas (CVF)\] than the scan that is normally used (EID-CTM).

Key facts

Study ID

NCT07582744

Run by

Duke University

People needed

200

Starts

2026-05-21

Expected to finish

2028-08-01

Last updated by the study team

2026-06-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patient,
• Confirmed diagnosis of SIH using International Classification of Headache Disorders criteria (third edition), and
• Brain MRI demonstrating at least one positive imaging finding for SIH (e.g., dural enhancement, venous sinus distention, brain sagging, pituitary engorgement, spontaneous subdural fluid collections).

You may not qualify if…

• Prior treatment of a CVF,
• Inability to undergo both exams (EID-CTM and PCD-CTM) if needed for diagnosis,
• Spine MRI demonstrating extradural CSF (confirming CSF leak type other than CVF), and
• inability to provide informed consent.

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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