OCTive: A New Horizon in MS Digital Solution

Enrolling by invitation

Conditions studied: Multiple Sclerosis

In brief

Multiple Sclerosis (MS) is a condition that affects the brain and spinal cord, leading to problems with movement, balance, and vision. This project will validate innovative tools developed for monitoring MS progression using advanced movement analysis and retinal imaging technologies. Two computer vision-based applications, Digi Motion and Digi Balance, will measure range of motion, centre of mass, balance, and stability. In parallel, a model will be trained to analyse eye images using Optical Coherence Tomography (OCT)-a non-invasive technique that captures detailed views of retinal structures, including the retinal nerve fibre layer (RNFL), ganglion cell-inner plexiform layer (GC-IPL), and macular thickness, which are key biomarkers of MS-related neuroaxonal loss. These tools will be evaluated in people with MS, comparing results with traditional clinical assessments to determine reliability and validity. By integrating movement and retinal biomarkers, this approach aims to create a comprehensive and personalised method for tracking disease progression.

Key facts

Study ID

NCT07582653

Run by

University of Exeter

People needed

10

Starts

2026-02-01

Expected to finish

2026-05-31

Last updated by the study team

2026-05-13

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• condition has been stable over a period of a month
• can walk at least 10 metres independently with or without their walking aids

You may not qualify if…

• pregnancy
• allergic to adhesive materials
• a condition that precludes safe participation in the assessment as indicated by the referring clinician
• insufficient mental capacity to consent

Where it is running

• University of Exeter Engineering Research Centre — Exeter, Devon, United Kingdom

Full record on ClinicalTrials.gov

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