sACB vs cACB in TKA
Starting soon · Not applicable
Conditions studied: Arthroplasty, Replacement, Knee
In brief
This study compares the analgesic efficacy of single-dose adductor canal block (sACB) versus continuous-dose adductor canal block (cACB) for postoperative pain management in total knee replacement patients. To ensure a high level of clinical accuracy, the investigation specifically focuses on a cACB cohort where ultrasound confirmation ensures the catheter remains correctly positioned for a full 48 hours. Participants are assigned to groups using a 1:1 randomization protocol via computer-generated tables to eliminate selection bias. Clinical consistency is maintained by using identical pharmacological agents across both groups: 0.5% Heavy Bupivacaine for spinal anesthesia and 0.5% ropivacaine with 1:200,000 epinephrine for the nerve block itself. Furthermore, both groups adhere to a standardized multimodal analgesic schedule to control for external variables. In the cACB group, intravenous patient-controlled analgesia (IV PCA) serves as a designated rescue therapy should the catheter fail. The primary technical evaluation occurs 48 hours post-surgery, utilizing ultrasound to verify catheter placement and quantify pain levels. Beyond immediate recovery, the study evaluates long-term success through Patient-Reported Outcome Measures (PROMs) at a 12-week follow-up, focusing on functional restoration and the patient's overall quality of life. By isolating the variable of catheter stability, the research aims to provide a definitive comparison of whether the continuous delivery of local anesthetic offers a statistically significant clinical advantage over a single-dose administration in the context of modern orthopedic recovery protocols.
Key facts
- Study ID
- NCT07581886
- Run by
- Yonsei University
- People needed
- 78
- Starts
- 2026-05-18
- Expected to finish
- 2028-01-31
- Last updated by the study team
- 2026-05-12
Who can join
Age: 40 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 40-80 yrs
- Scheduled for unilateral total knee arthroplatsy
- ASA I-III
- BMI 18-35 kg/㎡
- Able to read and understand consent form
You may not qualify if…
- Allergy to local anesthetics
- Infection at the block site
- History of neuropathy or peripheral nerve disease
- Coagulation disorders or use of anticoagulants (if discontinuation is not possible)
- Communication disorders or cognitive impairment
- Chronic opioid use (≥30 MME/day, 3 months or more)
- Severe chronic pain (NRS ≥7/10, 3 months or more)
- Renal impairment (eGFR <30 mL/min/1.73m²)
- Hepatic impairment (Child-Pugh C)
- Blood coagulation disorders
- Pregnancy
Full record on ClinicalTrials.gov
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