Effective Dose of Alfentanil Combined With Propofol for Laryngeal Mask Airway Insertion in Children

Starting soon · Phase 4

Conditions studied: Pediatric Anesthesia, Airway Management, General Anesthesia, LMA

In brief

This study uses a prospective, up-and-down sequential allocation method to determine the median effective dose (ED50) and 95% effective dose (ED95) of alfentanil combined with propofol for successful laryngeal mask airway (LMA) insertion in children aged 7-12 undergoing elective day surgery.

Key facts

Study ID

NCT07581665

Run by

Zhongshan Ophthalmic Center, Sun Yat-sen University

People needed

40

Starts

2026-05-01

Expected to finish

2027-03-30

Last updated by the study team

2026-05-12

Who can join

Age: 7 and older, up to 12. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 7 to 12 years
• Undergoing elective day surgery
• ASA physical status I-II
• Body Mass Index (BMI) between 14 and 24 kg/m²
• Accompanied by a fully capable guardian within 24 hours after discharge

You may not qualify if…

• Allergy to opioids
• Unresolved upper respiratory tract infection within the past 1 week
• Abnormal heart, lung, liver, or kidney function, or metabolic diseases
• Airway anatomical abnormalities (e.g., micrognathia, laryngomalacia, macroglossia) or OSAHS (Obstructive Sleep Apnea-Hypopnea Syndrome)
• Use of analgesics, sedatives, or other psychotropic drugs within the past 2 weeks
• Refusal to sign the informed consent form

Where it is running

• Department of Anesthesiology, Zhongshan Ophthalmic Center, Sun Yat-sen University — Guangzhou, Guangdong, China

Full record on ClinicalTrials.gov

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