Mesenchymal Stem Cells in the Treatment of Burn Wounds

Recruiting now · Not applicable

Conditions studied: Burn Injury, Burn Patients

In brief

Burn patients were randomly divided into the low-dose stem cell gel group, the high-dose stem cell gel group, and the placebo group (with only the gel), and received the same treatment under the same conditions simultaneously.

Key facts

Study ID

NCT07580755

Run by

The First Affiliated Hospital of Xinxiang Medical College

People needed

90

Starts

2026-04-27

Expected to finish

2028-12-31

Last updated by the study team

2026-05-12

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Voluntary participation and signing of the informed consent form;
• Burn patients, subjects requiring autologous skin grafting;
• Age 18 to 65 years old, gender not restricted;
• During this clinical study, single person, single donor skin area (lateral thigh or trunk) treatment;
• Skin burn area < 30% of total body surface area (TBSA);
• The donor skin area is the first time for donation, and the donor skin area is medium-thick skin (thickness approximately 0.4mm);
• The area of the excised skin flap ≥ 90 cm2;
• Able to cooperate with this study protocol and accept regular postoperative follow-up visits.

You may not qualify if…

• Those allergic to sodium alginate (gel component);
• Electric shock injuries, chemical burns, radiation injuries or combined with other traumas;
• Subjects with severe systemic diseases (judged by the researchers);
• Subjects with uncontrolled hypertension or diabetes (judged by the researchers);
• Pregnant or lactating women;
• Subjects whose condition may affect the study assessment or require the concurrent use of medical treatments that may affect the efficacy assessment;
• Subjects with acute or chronic kidney diseases, renal failure or serum creatinine level = 1.5 times the upper limit of normal value;
• Subjects with acute or chronic liver diseases, total bilirubin, alanine aminotransferase, aspartate aminotransferase = 2.0 times the upper limit of normal value;
• Subjects with a history of malignant tumors;
• Subjects who have participated in other clinical studies for less than 3 months;
• Subjects with mental disorders and without self-awareness, unable to express clearly;
• Subjects using immunosuppressants and those who have been using corticosteroids for a long time (more than 1 month) (excluding local application);
• Subjects with infectious diseases (any one of the four items positive in the test);
• Subjects with other severe systemic diseases;
• Other subjects that the researchers consider not eligible for inclusion.

Where it is running

• The First Affiliated Hospital of Xinxiang Medical College — Xinxiang, Henan, China (enrolling)

Full record on ClinicalTrials.gov

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