Platelets and Extracorporeal Membrane Oxygenation Veno-venous

Starting soon

Conditions studied: Extracorporeal Membrane Oxygenation Complication, Hemorrhage, Blood Platelet Disorder, Thrombosis

In brief

In severe lung or heart disease, ExtraCorporeal Membrane Oxygenation (ECMO) may be used temporarily and can be responsible for major haemorrhagic complications. Thrombocytopenia and possibly thrombopathy promote bleeding. The primary objective is to characterize platelet dysfunction by aggregometry tests over time. Secondarily, investigators seek a correlation between haemorrhagic complications at day 10 and markers of platelet action and dysfunction; also, with the level of anticoagulation and inflammation by biomarkers.

Key facts

Study ID

NCT07580469

Run by

University Hospital, Toulouse

People needed

40

Starts

2026-09-01

Expected to finish

2028-12-31

Last updated by the study team

2026-06-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged ≥ 18 years
• No objection to participation in the study, obtained from a relative or trusted person; if no relative is available, inclusion under emergency procedure (pending patient or relative non-opposition)
• Patients requiring admission to the general intensive care unit of Hôpital Rangueil for venovenous ECMO
• Equipped with an arterial catheter for blood sampling
• Ability to undergo the 4 blood draws relevant to the study
• Receiving therapeutic anticoagulation with unfractionated heparin
• Enrolled in a social security program or equivalent
• No measures for Limitation and Withdrawal of Therapy have been implemented

You may not qualify if…

• Minors
• Patients under court-appointed guardianship or conservatorship
• Pregnant or breastfeeding women
• Hematological disease (leukemia, lymphoma) or constitutional thrombocytopenia
• Platelet transfusion within 7 days prior to enrollment
• Indication for immediate emergency ECMO preventing blood sampling before placement
• Post-cardiotomy
• Patient on antiplatelet therapy
• Severe thrombocytopenia <50 G/L
• Other invasive mechanical support such as Impella®, intra-aortic balloon pump, or Left Ventricular Assist Device (LVAD)

Where it is running

• UHToulouse — Toulouse, France

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.