Acute Ocular Effects of Cigarette Smoking

Recruiting now

Conditions studied: Smoking ( Cigarette), Cornea, Anterior Eye Segment Measurements

In brief

This prospective study aims to evaluate the short-term effects of smoking on corneal tomographic and biometric measurements in healthy adults. After baseline examinations and measurements are taken in both smoking and non-smoking participants, the same measurements will be repeated after 10 minutes of external exposure, and within-group and between-group changes will be compared. The aim of the study is to determine whether acute smoking exposure leads to measurable immediate changes in corneal tomographic and biometric parameters.

Key facts

Study ID: NCT07580040
Run by: Istanbul University
People needed: 90
Starts: 2026-02-15
Expected to finish: 2026-05-01
Last updated by the study team: 2026-05-12

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Healthy adults aged 18 to 60 years
Current smokers in the smoking group
Never-smokers in the control group
Willing and able to undergo ophthalmic examination and Pentacam AXL measurements

You may not qualify if…

History of ocular surgery or ocular trauma
Presence of corneal disease, retinal disease, or ocular surface disorder
Clinically significant dry eye disease
Contact lens use within the last 2 weeks
Use of medications that may affect the ocular surface or pupillary dynamics, including anticholinergics or sympathomimetics
Systemic diseases such as diabetes mellitus or hypertension
Former smoking history in the control group
Use of electronic cigarettes or other tobacco products
Inability to cooperate adequately for accurate measurement

Where it is running

Istanbul University, Istanbul Faculty of Medicine — Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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