Explore the Impacts of Theta Burst Stimulation Over the Right Inferior Frontal Gyrus in Autism Spectrum Disorder: Combination of Clinical Symptoms, Neuropsychological Function and MRI
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Autism Spectrum Disorder, Theta Burst Stimulation, Right Inferior Frontal Gyrus
In brief
Exploring the therapeutic efficacy of Theta Burst Stimulation (TBS) over the right inferior frontal gyrus (RIFG) in autism, including changes in core symptoms, adaptive functioning, neuropsychological performance, and neurophysiological signals.
Key facts
- Study ID
- NCT07579494
- Run by
- Chang Gung Memorial Hospital
- People needed
- 60
- Starts
- 2026-05-05
- Expected to finish
- 2030-12-31
- Last updated by the study team
- 2026-05-12
Who can join
Age: 8 and older, up to 30. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Participants aged 8 to 30 years with a clinical diagnosis of Autism Spectrum Disorder (ASD), confirmed by the ADOS-2 (Autism Diagnostic Observation Schedule, Second Edition).
- DSM-5 severity level of ASD: level 1 or level 2
- Participants who have been on a stable treatment regimen prior to the study, or those for whom conventional treatments have been assessed as ineffective by a physician, or those who decline conventional treatment.
- A score of ≥ 15 on the University of California Brief Assessment of Capacity to Consent (UBACC) and demonstrated understanding of study aims and risks via the teach-back method.
You may not qualify if…
- Previous or current severe neurological disorders, especially epilepsy, visual or auditory impairments
- Previous or current severe systemic diseases such as cardiovascular disease, diabetes or hypertension
- Previous or current severe brain injury
- Implementation of metal materials such as a pacemaker or medication pump
- Previous or current severe psychiatric disorders such as schizophrenia, bipolar disorder or substance abuse
- Pregnancy
- Presence of significant brain abnormalities, such as intracranial space-occupying lesions
- Previous brain surgery or central nerve system infection
- Concurrent use of medications which increased the risk of seizure attack
- Participate in another clinical trial within one month
- With damaged skin at the stimulated region
- With multiple sclerosis
- With large ischemic scars
- Have experienced sleep disorders during brain stimulation
- Severe alcoholism
- Concurrent use of antiepileptic drugs
- Uncontrollable migraines due to increased intracranial pressure
- Unsuitable for MRI (e.g. those with claustrophobia)
- Unsuitable for EEG
- DSM-5 severity level of ASD: level 3
- Current major depressive disorder
- Suicidal ideation within one year
- Currently taking tricyclic antidepressants (TCAs), analgesics, or any medications known to lower the seizure threshold.
- Withdrawal Criteria:
- Seizure attack during the study period
Where it is running
- Chang Gung Memorial Hospital — Taoyuan, Taiwan (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.