Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery

Enrolling by invitation

Conditions studied: Unilateral Vocal Cord Paralysis, Vocal Cord Atrophy

In brief

The goal of this observational study is to learn about the long-term outcomes of Laryngeal Framework Surgery (LFS) in patients with Unilateral Vocal Fold Paralysis (UVFP) or Vocal Fold Atrophy (VFA). The main questions it aims to answer are: * Whether LFS technique (implant material, addition of arytenoid adduction) is associated with differences in outcomes such as complication rate, duration of surgery, hospital stay length, and quality of voice post-surgery. * Whether UVFP or VFA diagnosis is associated with differences in outcomes such as complication rate, duration of surgery, hospital stay length, and quality of voice post-surgery. Participants who are determined by their clinician to need LFS for their UVFP or VFA will undergo the procedure, attend follow-up appointments, and complete surveys about their voice and swallowing ability as they would as part of their regular medical care.

Key facts

Study ID

NCT07579364

Run by

University of California, San Francisco

People needed

500

Starts

2025-10-28

Expected to finish

2028-01-01

Last updated by the study team

2026-05-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Over 18 years of age
• Diagnosed UVFP or VFA
• English speaking
• willing and able to follow up for 2 years

You may not qualify if…

• under 18
• non-English speaking

Where it is running

• University of California, San Diego — La Jolla, California, United States
• University of Southern California — Los Angeles, California, United States
• University of California, San Francisco — San Francisco, California, United States
• University of Miami — Miami, Florida, United States
• Massachusetts Eye and Ear Infirmary — Boston, Massachusetts, United States
• Washington University in St. Louis — St Louis, Missouri, United States
• Wake Forest University — Winston-Salem, North Carolina, United States
• University of Cincinnati — Cincinnati, Ohio, United States
• Ohio State University — Columbus, Ohio, United States
• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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