IMPACT-HTN Study of Patients With Hypertension
Starting soon
Conditions studied: Hypertension (HTN), Hypertension, Blood Pressure, High
In brief
An estimated 120 million people have high blood pressure (hypertension) in the US, of which approximately 10% have resistant hypertension. This study aims to enroll patients who continue to have hypertension while being treated with at least two medications. The study will follow patients for approximately 3 months and collect real-world information on changes in their health to identify an ideal patient profile that would benefit from 4th-line antihypertensive therapies, including, but not limited to, FDA-approved aprocitentan, renal denervation, mineralocorticoid receptor antagonists, etc.
Key facts
- Study ID
- NCT07579260
- Run by
- Vivek Bhalla
- People needed
- 100
- Starts
- 2026-07-01
- Expected to finish
- 2027-04-01
- Last updated by the study team
- 2026-06-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Signed and dated informed consent form
- Ability to answer survey questions and to report blood pressure reading monthly
- Male and female participants; 18 years or older
- Treated with at least 2 antihypertensive therapies of different pharmacological classes for at least 4 weeks before the screening visit
- Mean Sitting Systolic Blood Pressure (SiSBP) greater or equal to 130 mmHg
You may not qualify if…
- Confirmed severe hypertension (grade 3) defined as SiSBP greater than or equal to 180 mmHg and/or Sitting Diastolic Blood Pressure (SiDBP) greater than or equal to 110 mmHg
- Clinically significant unstable cardiac disease at screening or in the past in the opinion of the investigator
- Heart failure NYHA functional class III and IV or NT-proBNP > 500 pg/mL
- Severe renal insufficiency or eGFR < 15 mL/min/1.73m2
- Moderate to severe hepatic impairment (Child-Pugh B and C) or elevated aminotransferase (> 3 x ULN)
Where it is running
- Stanford University Hypertension Center — Palo Alto, California, United States
- Duke University Hospital — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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