The Effects of High-Intensity Interval Training on Gait, Balance, and Cognitive Functions in Individuals With Multiple Sclerosis

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Conditions studied: Multiple Sclerosis, High-intensity Interval Training, Gait, Balance, Cognition, Biomarkers

In brief

This study aims to comparatively investigate the effects of low-volume High-Intensity Interval Training (HIIT) versus Moderate-Intensity Continuous Training (MICT) on gait, balance, cognitive functions, and neurovascular biomarkers (BDNF, VEGF) in individuals with Multiple Sclerosis (MS). This randomized controlled trial will be conducted at Hacettepe University, Faculty of Physical Therapy and Rehabilitation.

Key facts

Study ID

NCT07578740

Run by

Hacettepe University

People needed

40

Starts

2026-07-01

Expected to finish

2028-06-01

Last updated by the study team

2026-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with Multiple Sclerosis by a neurologist (Hacettepe University Hospitals, Neurology Outpatient Clinic)
• Age 18 years and older
• EDSS score between 0 and 4
• Score of 24 or above on the Standardized Mini Mental State Examination
• No relapse in the past 3 months
• Medically stable for at least 6 months

You may not qualify if…

• Any additional cardiopulmonary, neurological, or systemic disease other than MS

Where it is running

• Hacettepe University — Ankara, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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