Biomedical Signal Extraction From Symptom Descriptions: An Observational Registry Using the OpenGenome Platform

Recruiting now

Conditions studied: Signs and Symptoms, Fever, Myalgia, Skin Diseases, Hemorrhagic Fever With Renal Syndrome, Zoonoses

In brief

This registry prospectively collects anonymized free-text symptom descriptions submitted voluntarily by adults through the OpenGenome platform at opengenome.bio. For each submission, the system retrieves real biomedical literature from PubMed and ClinicalTrials.gov in parallel, applies a constrained reasoning model operating under a strict output schema, and returns a structured biological signal report. The study evaluates the internal consistency of extracted signals, the calibration of confidence scores relative to dataset size and symptom specificity, and the distribution of biological signal categories across a large anonymous population. No intervention is assigned. No participant contact occurs. All data is anonymized at the point of collection.

Key facts

Study ID
NCT07578610
Run by
OpenGenome
People needed
1000
Starts
2026-05-05
Expected to finish
2028-05-30
Last updated by the study team
2026-05-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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