Impact of Iridotomy/Iridectomy Size on Postoperative Pupillary Block and Dysphotopsia Following DMEK

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Conditions studied: Pupillary Block After DMEK, Laser Iridotomy / Surgical Iridectomy, Dysphotopsia, Descemet Membrane Endothelial Keratoplasty (DMEK)

In brief

Descemet membrane endothelial keratoplasty (DMEK) is the standard surgical treatment for corneal endothelial disorders. A postoperative pupillary block may occur despite routine preoperative laser iridotomy or intraoperative surgical iridectomy. Insufficient size or incomplete patency of the iridotomy/iridectomy (IT) may contribute to this complication, while excessively large openings may be associated with postoperative dysphotopsia. This prospective observational study investigates the association between IT size measured by anterior segment optical coherence tomography (AS-OCT) and the occurrence of postoperative pupillary block and dysphotopsia after DMEK.

Key facts

Study ID: NCT07577635
Run by: University of Leipzig
People needed: 100
Starts: 2026-06-01
Expected to finish: 2027-07-01
Last updated by the study team: 2026-07-02

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adults aged ≥ 18 years
Patients undergoing Descemet membrane endothelial keratoplasty (DMEK) at the Department of Ophthalmology, University Hospital Leipzig
Preoperative Nd:YAG laser iridotomy or intraoperative surgical iridectomy performed as part of standard care
Ability to provide written informed consent
Willingness to complete the postoperative dysphotopsia questionnaire

You may not qualify if…

Inability to provide informed consent or refusal to participate
Pre-existing surgical iridectomy
Missing or incomplete preoperative or postoperative anterior segment OCT data
Active anterior uveitis or panuveitis at the time of surgery

Full record on ClinicalTrials.gov

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