AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)

Recruiting now

Conditions studied: Coronary Artery Disease (CAD), Computed Tomography Angiography, Biomarkers, AI (Artificial Intelligence), Lipoprotein(a), Atheroscleroses, Coronary, Myocardial Ischemia

In brief

The goal of this observational study is to learn if AI-assisted cardiac CT imaging can improve cardiovascular risk stratification and prediction of future coronary events in an adult population undergoing clinically indicated cardiac CT. The main questions it aims to answer are: * Can AI-enhanced cardiac CT accurately assess cardiovascular risk in a real-world adult population? * How do CT-derived plaque characteristics correlate with clinical, biochemical, and lifestyle risk factors? Researchers will compare subgroups (e.g., patients with different risk profiles, biomarkers, or imaging findings, and a subset undergoing OCT imaging) to see if differences in imaging and clinical parameters are associated with cardiovascular risk and plaque vulnerability. Participants will: * Provide informed consent and medical history/demographic information * Undergo blood sampling for cardiovascular and metabolic biomarkers * Have a resting ECG performed * Complete a detailed lifestyle and health questionnaire * Receive a non-invasive cardiac CT scan interpreted by an expert * Potentially receive heart rate-lowering medication (e.g., metoprolol) if required for imaging quality * Be referred for further clinical evaluation if clinically indicated 

Key facts

Study ID

NCT07577609

Run by

University of Galway

People needed

10000

Starts

2022-12-21

Expected to finish

2032-12-21

Last updated by the study team

2026-05-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged ≥18 years
• Undergoing clinically indicated cardiac CT
• Able and willing to provide informed consent

You may not qualify if…

• History of malignancy
• Abnormal renal function (e.g., eGFR or serum creatinine outside reference range)
• Contraindications to iodinated contrast agents or CT imaging

Where it is running

• Clinical Research Facility — Galway, Ireland (enrolling)

Full record on ClinicalTrials.gov

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