Combined RSBI, TOF, and BIS for Prediction of Extubation Success

Starting soon

Conditions studied: Extubation Success, Extubation Failure, Postoperative Respiratory Complications

In brief

This prospective observational study aims to evaluate the predictive value of the combined use of the rapid shallow breathing index, train-of-four ratio, and bispectral index for extubation success after general anesthesia. Adult patients undergoing elective surgery under general anesthesia and planned for extubation in the operating room will be included. Before extubation, RSBI, TOF ratio, BIS value, respiratory parameters, and relevant perioperative data will be recorded. The decision to extubate will be made by the attending anesthesiologist according to routine clinical practice and will not be altered by the study protocol. Patients will be followed for 30 minutes after extubation to assess extubation success or the development of complications such as desaturation, laryngospasm, need for airway intervention, mask ventilation, or reintubation. The primary aim is to determine whether the combined RSBI, TOF, and BIS model predicts extubation success more accurately than each parameter alone.

Key facts

Study ID

NCT07577453

Run by

Gaziantep City Hospital

People needed

150

Starts

2026-06-15

Expected to finish

2026-08-15

Last updated by the study team

2026-05-13

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age between 18 and 80 years
• ASA physical status I-III
• Patients scheduled for elective surgery under general anesthesia
• Patients undergoing endotracheal intubation during general anesthesia
• Patients receiving neuromuscular blocking agents during anesthesia
• Patients planned for extubation in the operating room
• Availability of pre-extubation RSBI, TOF ratio, and BIS measurements
• Written informed consent obtained from the patient

You may not qualify if…

• Emergency surgery
• Age <18 years or >80 years
• ASA physical status IV or higher
• Known or anticipated difficult airway
• Anticipated difficult extubation
• Preoperative mechanical ventilation
• Planned postoperative mechanical ventilation or transfer to the intensive care unit while intubated
• Known neuromuscular disease
• Severe chronic respiratory failure
• Severe chronic obstructive pulmonary disease associated with respiratory failure
• Significant neurological disease affecting respiratory drive or level of consciousness
• Conditions or medications that may interfere with reliable neuromuscular monitoring
• Inability to obtain reliable RSBI, TOF ratio, or BIS measurements
• Refusal to participate
• Incomplete perioperative or post-extubation outcome data

Full record on ClinicalTrials.gov

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