Single Microdose Trial- CXCR4 PET Tracer - Pharmacokinetics and Pharmacodynamics of [68Ga]Ga-R54, a Radiopharmaceutical Directed Toward CXCR4 in Patients With Advanced Solid Neoplasia.
Recruiting now · Early Phase 1
Conditions studied: Advanced Solid Tumor, Multiple Myeloma
In brief
Phase 1, monocentric, open labeled, no profit "Microdose" trial. A single microdose of the new \[68Ga\]Ga-R54 PET radiopharmaceutical directed against CXCR4 will be injected into patients with advanced solid tumor or multiple myeloma to evaluate the binding.
Key facts
- Study ID
- NCT07577206
- Run by
- National Cancer Institute, Naples
- People needed
- 10
- Starts
- 2025-01-24
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-05-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients > 18 years
- Patients with histological diagnosis of solid neoplasm (breast, lung, colon, ovary, pancreas) in advanced stages or multiple myeloma evaluated by PET/CT with [18F]FDG carried out in the 3 months prior to enrollment. The neoplasm must express the CXCR4 receptor by immunohistochemistry
- Patients with ECOG performance status 0-2, able to undergo the scheduled diagnostic procedure (PET/CT with [68Ga]Ga-R54).
- Patients with alkaline phosphatase (AP), alanine aminotransferase (ALT), and aspartate aminotransferase <3 x upper limit of reference range and total bilirubin <2.0 mg/dL
- Patients with creatinine < 1.5 x upper limit of reference range or 24-hour creatinine clearance > 50 mL/min
- Negative serum pregnancy test (b-hCG) for women of childbearing age before administration of [68Ga]Ga-R54).
- Signature of informed consent indicating that the patient (or legal representative) has been informed of all aspects pertinent to the study
- Willingness and ability to comply with scheduled visits, laboratory tests and other study procedures.
You may not qualify if…
- Presence of active infections (e.g. requiring antibiotic therapy) or other serious concomitant illness, which, in the opinion of the investigator, would place the patient at undue risk or interfere with the study
- Declared chronic active hepatitis (hepatitis B / C)
- Declared active autoimmune diseases
- Recovery from major trauma including surgery within 4 weeks of study enrollment
- Presence of neurodegenerative diseases
- Pregnancy and/or breastfeeding
- Any conditions that in the opinion of the investigator could hinder compliance with the study protocol
- Patients who have not signed consent to participate in the study
Where it is running
- Istituto Nazionale Tumori Fondazione G. Pascale - SC Medicina Nucleare e Terapia Metabolica — Naples, Italia, Italy (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.