Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery

Starting soon · Phase 4 · Has a placebo group

Conditions studied: Older Patients, Surgery, Dexmedetomidine, Esketamine, Transcranial Direct Current Stimulation, Cognitive Function, Survival

In brief

Neurocognitive complications, mainly delirium and neurocognitive disorders, are common cerebral complications in older patients after surgery and associated with worse long-term outcomes. An ongoing 2×2 factorial trial conducted by the investigators plan to test the effects of perioperative dexmedetomidine-esketamine combination and transcranial direct current stimulation (tDCS) on postoperative neurocognitive complications in older patients. This long-term follow-up of the ongoing trial aims to investigate the effects of perioperative dexmedetomidine-esketamine combination and tDCS on long-term outcomes in older patients after noncardiac surgery.

Key facts

Study ID

NCT07576543

Run by

Peking University First Hospital

People needed

1160

Starts

2026-06-01

Expected to finish

2031-06-01

Last updated by the study team

2026-05-12

Who can join

Age: 65 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 65 to 90 years;
• Preoperative Mini-Mental State Examination (MMSE) score < 27 points, indicating possible cognitive impairment ranging from mild to moderate;
• Scheduled to undergo elective non-cardiac, non-neurosurgical surgery under general anesthesia, with an expected surgical duration > 1 hour;
• Required patient-controlled intravenous analgesia (PCIA) after surgery.

You may not qualify if…

• Preoperative inability to communicate due to coma, severe dementia, endstage disease, or language impairment;
• History of schizophrenia, epilepsy, Parkinson's disease, brain trauma/surgery, or myasthenia gravis;
• Presence of metal implants in the intracranial or cervical region (such as cochlear implants, aneurysm clips, deep brain stimulation electrodes), or skin damage or severe skin disease on the head;
• Severe cardiac dysfunction (left ventricular ejection fraction < 30%), comorbid with sick sinus syndrome, severe bradycardia (heart rate < 50 bpm), or second-degree or higher atrioventricular block, or implantation of a cardiac pacemaker;
• Uncontrolled hyperthyroidism or pheochromocytoma;
• Severe liver dysfunction (Child-Pugh class C), severe renal dysfunction (requiring dialysis), or ASA classification ≥ IV;
• Allergy to dexmedetomidine or esketamine;
• Participation in other clinical studies within the past 3 months;
• Other conditions that are deemed unsuitable for study participation.

Where it is running

• Peking University First Hospital — Beijing, Beijing Municipality, China
• Fujian Medical University Union Hospital — Fuzhou, Fujian, China
• Peking University Shenzhen Hospital — Shenzhen, Guangdong, China
• Xijing Hospital, Air Force Medical University — Xi'an, Shaanxi, China
• First Affilited Hospital, School of Medicine, Zhejiang University — Hangzhou, Zhejiang, China
• Second Affilited Hospital, School of Medicine, Zhejiang University — Hangzhou, Zhejiang, China

Full record on ClinicalTrials.gov

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