Specificities of Atypical Non AutoImmune Diabetes (ANAID) in the French West Indies
Starting soon
Conditions studied: Metabolic Diseases, Diabetes Mellitus (Type 2), Genetic Variation, Genetic Profile, Glucose Metabolism Disorders
In brief
Genetics variants could be involved in atypical non-autoimmune diabetes revealed by ketoacidosis. The objective of this research will be to determine the relationships between the genetic variants already described in known monogenic diabetes or identified as involved in glucose metabolism and its regulation, in insulin signaling pathways or in insulin secretion itself in subjects of African and Indian ancestry with atypical forms of non autoimmune diabetes.
Key facts
- Study ID
- NCT07576374
- Run by
- Centre Hospitalier Universitaire de la Guadeloupe
- People needed
- 118
- Starts
- 2026-06-01
- Expected to finish
- 2029-09-01
- Last updated by the study team
- 2026-05-08
Who can join
Age: 18 and older, up to 47. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Phenotypic criteria :
- Subjects from Indian or African Ancestry self-declared
- Age criteria at diagnosis:
- Early onset of diabetes: patient aged between 18 and 47 years at the time of diagnosis of diabetes Clinical criteria: at least 2 criteria Labeled type 2 diabetic
- Patient hospitalized for:
- Ketoacid decompensation Significant weight loss (more than 10% in less than 6 months) without obvious etiology Lipodystrophic / lipoatrophic appearance Presence of an associated myopathy or deafness Presence of early inaugural nephropathy or within 3 years after diagnosis Presence of early inaugural heart disease or within 3 years after diagnosis Poor response to non-insulin treatments despite good adherence
- Biological criteria:
- Absent T1D autoantibodies:
- Anti-islet antibodies (ICA) Anti-IA2 antibodies Anti-insulin antibodies Anti-ZnT8 antibodies Anti-GAD antibodies
- Other criteria:
- Informed consent signed by the patient
You may not qualify if…
- Type 1 diabetes (T1D) Presence of T1D antibodies Secondary diabetes (pancreas diseases, endocrine diseases, drug intake, infection) Other associated autoimmune pathologies Pregnancy Refusal to participate
Where it is running
- Centre Hospitalier Universitaire de la Guadeloupe — Les Abymes, Guadeloupe, Guadeloupe
Full record on ClinicalTrials.gov
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