International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia

Enrolling by invitation

Conditions studied: Hyponatremia Symptomatic, Osmotic Demyelination Syndrome, Cerebral Edema

In brief

Electronic medical records dating back as far as available for each center to identify patients admitted to the hospital with a serum sodium ≤110 mmol/l. Data on patient demographics, presenting symptoms, vital signs, laboratory findings, treatment given, sodium correction rates, presence of risk factors for osmotic demyelination syndrome (ODS) and outcomes including suspected and MRI-confirmed ODS, in-hospital death, and imaging confirmation of cerebral edema

Key facts

Study ID

NCT07576036

Run by

Rochester General Hospital

People needed

800

Starts

2023-11-01

Expected to finish

2026-06-30

Last updated by the study team

2026-05-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Serum sodium ≤110 mmol/L at admission to the hospital

You may not qualify if…

• Blood glucose >15 mmol/L, spurious laboratory dataa

Where it is running

• University of Pittsburgh School of Medicine — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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