A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Overweight, Obesity, Overweight and/or Obesity, Overweight or Obesity, Overnutrition, Nutrition Disorders, Nutritional and Metabolic Diseases, Body Weight

In brief

This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).

Key facts

Study ID

NCT07575932

Run by

Pfizer

People needed

872

Starts

2026-05-11

Expected to finish

2028-01-05

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Eligible participants for this study include:
• adults aged 18 years or older with
• obesity (BMI of 30.0 kg/m2 to 50.0 kg/m2) or with
• overweight (BMI of 27.0 kg/m2 to <30.0 kg/m2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit.

You may not qualify if…

• Participants who are not eligible include those with diabetes mellitus, a body weight change of >5% or use of weight loss medications in the 12 weeks prior to screening, a history of or plan for surgical treatment for obesity, and those who are unable or unwilling to comply with contraceptive requirements or are pregnant or lactating.

Where it is running

• Clinical Research Institute of Arizona — Sun City West, Arizona, United States (enrolling)
• Arizona Clinical Trials (ACT) - Tucson — Tucson, Arizona, United States (enrolling)
• San Fernando Valley Health Institute — Canoga Park, California, United States (enrolling)
• Ark Clinical Research — Fountain Valley, California, United States (enrolling)
• Paragon Rx Clinical — Garden Grove, California, United States (enrolling)
• Torrance Clinical Research Institute, Inc. — Lomita, California, United States (enrolling)
• Ark Clinical Research — Long Beach, California, United States (enrolling)
• Collaborative Neuroscience Research, LLC — Los Alamitos, California, United States (enrolling)
• Paradigm Clinical Research-Modesto — Modesto, California, United States (enrolling)
• Paradigm Clinical Research Centers, LLC — San Diego, California, United States (enrolling)
• University Clinical Investigators, Incorporated — Tustin, California, United States (enrolling)
• Diablo Clinical Research, LLC dba Flourish Research — Walnut Creek, California, United States (enrolling)
• AGA Clinical Trials — Hialeah, Florida, United States (enrolling)
• Westside Center for Clinical Research — Jacksonville, Florida, United States (enrolling)
• New Horizon Research Center — Miami, Florida, United States (enrolling)
• Charter Research — Orlando, Florida, United States (enrolling)
• Atlanta Diabetes Associates — Atlanta, Georgia, United States (enrolling)
• Clinical Research Atlanta — Stockbridge, Georgia, United States (enrolling)
• Koch Family Medicine Clinical Research/Elite Research Network — Morton, Illinois, United States (enrolling)
• Bioluminux Clinical Research Illinois — Naperville, Illinois, United States (enrolling)
• Johnson County Clinical Trials — Lenexa, Kansas, United States (enrolling)
• DelRicht Research — Mandeville, Louisiana, United States (enrolling)
• DelRicht Research — Prairieville, Louisiana, United States (enrolling)
• Patient First Clinical Trials (PFCTRIALS) — Lutherville, Maryland, United States (enrolling)
• Arizona Clinical Trials-Chandler — Chandler, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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