Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

Recruiting now · Phase 3

Conditions studied: Obesity or Overweight

In brief

Efficacy, safety and tolerability of switching from GLP-1RA to maridebart cafraglutide in adults with obesity or overweight.

Key facts

Study ID

NCT07575399

Run by

Amgen

People needed

300

Starts

2026-05-11

Expected to finish

2028-02-28

Last updated by the study team

2026-07-23

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Body Mass Index (BMI) ≥ 25 at screening.
• Weight loss of ≥ 10% on weekly GLP-1 RA.
• Stable body weight.
• Stable dose of GLP-1RA.
• Stable gastrointestinal (GI) tolerability.
• Contraception for females.
• Willingness to follow trial procedures for the duration of the trial.

You may not qualify if…

• Obesity induced by other endocrine disorders (ex: Cushing's syndrome).
• Previous or planned surgical, endoscopic or device-based treatment for obesity.
• History of malignancy.
• Type 1/Type 2 diabetes mellitus (DM).
• Family or personal history of medullary thyroid cancer.
• Previous participation in a Maridebart Cafraglutide trial.

Where it is running

• Cahaba Research, Inc. — Pelham, Alabama, United States (enrolling)
• Arizona Clinical Trials — Chandler, Arizona, United States (enrolling)
• Epic Medical Research - Sun City — Sun City, Arizona, United States (enrolling)
• Desert Oasis Healthcare Medical Group — Palm Springs, California, United States (enrolling)
• Inland Empire Liver Foundation — Rialto, California, United States (enrolling)
• Peninsula Research Associates — Rolling Hills Estates, California, United States (enrolling)
• Apex Clinical Research — San Diego, California, United States (enrolling)
• Southern California Clinical Research — Santa Ana, California, United States (enrolling)
• University of Florida Department of Medicine — Gainesville, Florida, United States (enrolling)
• Aga Clinical Trials — Hialeah, Florida, United States (enrolling)
• South Florida Clinical Research — Margate, Florida, United States (enrolling)
• New Horizon Research Center — Miami, Florida, United States (enrolling)
• Research Institute of South Florida — Miami, Florida, United States (enrolling)
• Clinical Neuroscience Solutions — Orlando, Florida, United States (enrolling)
• Florida Institute for Clinical Research — Orlando, Florida, United States (enrolling)
• Progressive Medical Research — Port Orange, Florida, United States (enrolling)
• Charter Research - The Villages — The Villages, Florida, United States (enrolling)
• Nsc Research — Johns Creek, Georgia, United States (enrolling)
• Rophe Adult and Pediatric Medicine/Sky Clinical Research Network Group — Union City, Georgia, United States (enrolling)
• North Georgia Clinical Research — Woodstock, Georgia, United States (enrolling)
• Solaris Clinical Research — Meridian, Idaho, United States (enrolling)
• Endeavor Health — Skokie, Illinois, United States (enrolling)
• Pennington Biomedical Research Center — Baton Rouge, Louisiana, United States (enrolling)
• Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division — Troy, Michigan, United States (enrolling)
• Sky Integrative Medical Center — Ridgeland, Mississippi, United States (enrolling)

Full record on ClinicalTrials.gov

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