Trial Evaluating Hypo-fractionated Accelerated Versus Conventional Fractionated Adjuvant RT in Head & Neck Malignancies
Recruiting now · Phase 2/Phase 3
Conditions studied: Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)
In brief
Hypo-fractionated radiotherapy reduces the OTT (overall treatment time) which may in turn reduce rapid accelerated repopulation of clonogenic cells during waiting period after surgery. If this holds true, there is a potential to achieve better loco-regional control in with PORT for HNSCC. There is a strong radiobiological and economic rationale for delivery hypo-fractionated radiotherapy in HNSCC. The HYPCON III trial will be aimed to reduce the number of fractions by 50% (30 fr to 15 fr)
Key facts
- Study ID
- NCT07573956
- Run by
- All India Institute of Medical Sciences
- People needed
- 369
- Starts
- 2026-02-10
- Expected to finish
- 2028-12-30
- Last updated by the study team
- 2026-05-07
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with pT1-4 squamous cell carcinoma of oral cavity/ oropharynx/ larynx/ hypopharynx with any of the intermediate risk features:
- Positive lymph node (s)
- Perineural invasion
- Lympho-vascular invasion
- Close margins
- Age 18-80yrs
- ECOG performance status 0-1at time of surgery
- Informed consent
- Available FOR long term follow-up
You may not qualify if…
- High risk factors following resection: positive-margin(s)and/or extra nodal extension (ENE)
- pT1-2disease and no high-risk features (LVSI, PNI, Close margins,pN0)
- Patients receiving Neo-adjuvant or concurrent Chemotherapy
- Non-Squamous Histology
- Distant metastasis
- Synchronous or second primary malignancy outside of the oropharynx, oral cavity, larynx and hypopharynx
- Pregnant females or nursing mothers due to the probability of congenital anomalies and potential of this regimen to harm nursing infants.
- Prior Radiotherapy to head and neck region
Where it is running
- Dr. Aman Sharma, Associate Professor, Radiation Oncology, NCI, AIIMS — Jhajjar, Haryana, India (enrolling)
Full record on ClinicalTrials.gov
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