Effect of Pursed-Lip Breathing With Different I:E Ratios on Respiratory Outcomes in COPD Patients

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Conditions studied: Chronic Obstructive Pulmonary Disease (COPD)

In brief

The goal of this clinical trial is to evaluate whether different inspiratory-expiratory (I:E) ratios in the pursed-lip breathing (PLB) technique can improve respiratory outcomes in patients with stable Chronic Obstructive Pulmonary Disease (COPD) aged 40 years and older. The primary purpose is to determine whether a specific breathing intervention can improve respiratory function. The main questions it aims to answer are: Does PLB with different I:E ratios (1:3, 1:4, and 1:5) reduce respiratory rate in COPD patients? Does PLB with different I:E ratios improve oxygen saturation and reduce dyspnea severity? Researchers will compare PLB with I:E ratios of 1:3, 1:4, and 1:5 and a control group receiving standard care to see if different ratios produce different effects on respiratory rate, oxygen saturation, and dyspnea levels. Participants will: Perform pursed-lip breathing using assigned I:E ratios (1:3, 1:4, or 1:5) for 10 minutes Be assigned to either an intervention group or a control group (standard care) Have their respiratory rate measured before and after the intervention Have their oxygen saturation measured using a pulse oximeter Report their dyspnea level using the Modified Borg Scale before and after the intervention

Key facts

Study ID

NCT07573826

Run by

Scholastica Fina Aryu Puspasari

People needed

122

Starts

2026-05-04

Expected to finish

2026-08-14

Last updated by the study team

2026-05-07

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with stable COPD
• Age ≥ 40 years
• Able to follow breathing instructions
• Willing to participate and provide informed consent

You may not qualify if…

• Cognitive impairment or decreased consciousness
• Severe cardiovascular disease (heart failure, coronary artery disease, pulmonary hypertension)
• Asthma-COPD overlap (ACO)
• Acute respiratory infection (e.g., pneumonia)
• Neuromuscular disorders affecting respiratory muscles

Full record on ClinicalTrials.gov

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