CHAMP Lung Cancer Screening Program

Recruiting now · Not applicable

Conditions studied: Lung Cancer, Early Lung Cancer Detection

In brief

The U.S. Preventive Services Task Force recommends annual lung cancer screening (LCS) with low-dose CT for adults aged 50-80 with a ≥20 pack-year smoking history who currently smoke or quit within the past 15 years. Despite insurance coverage, only 17% of eligible Iowans were screened in 2024. Barriers include the complexity of screening and competing demands in primary care. To address these challenges, investigators propose a two-part intervention: a blood-based screening test to simplify LCS and a community pharmacist-led referral program integrated into routine pharmacy care. Eligible patients will be identified at Greenwood Pharmacy in Waterloo, Iowa. Interested individuals will be consented by a pharmacist and engaged in shared decision-making about LCS. Participants may decline screening, complete the DELFI Diagnostics FirstLook lung cancer screening blood test, or pursue CT screening through their primary care physician. Those choosing the blood test will be referred to Cedar Valley Family Medicine. Patients with a positive result will complete a standard shared decision-making visit with their PCP and, if appropriate, undergo confirmatory CT imaging. Patients with a negative result will enter a screening cohort and be re-screened annually for an additional year.

Key facts

Study ID

NCT07572773

Run by

Jill Kolesar

People needed

300

Starts

2026-06-12

Expected to finish

2028-06-01

Last updated by the study team

2026-06-16

Who can join

Age: 50 and older, up to 77. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• aged 50-77
• smoking pack-year history of ≥ 20 years
• current smoker or quit smoking 15 or less years ago
• ability to understand and willingness to sign a written informed consent document

You may not qualify if…

• self-report of lung cancer screening in the last 12 months
• psychiatric illness/social situations that would limit compliance with study requirements

Where it is running

• University of Iowa — Iowa City, Iowa, United States (enrolling)
• Cedar Valley Primary Care & Walk-In Clinic — Waterloo, Iowa, United States (enrolling)
• Greenwood Pharmacy and Compounding Center — Waterloo, Iowa, United States (enrolling)

Full record on ClinicalTrials.gov

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