Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine

Recruiting now · Not applicable

Conditions studied: Pain From onabotulinumtoxinA Injections

In brief

People find the injections used in onabotulinumtoxinA (Botox®) uncomfortable. This study will test whether putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside the front of each nostril for 5 minutes before the injections reduces injection pain compared with cotton soaked in saline (salt water).

Key facts

Study ID

NCT07571889

Run by

Association of Migraine Disorders

People needed

18

Starts

2026-03-03

Expected to finish

2027-01-01

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged ≥18 years
• Any gender
• Able to provide informed consent
• Meets clinical criteria for onabotulinumtoxinA for chronic migraine (minimum of 2 days of disability per month due to facial or headache pain, or 8 headache days per month, or more than 15 headaches per month)
• Scheduled for modified PREEMPT injections at the clinical site

You may not qualify if…

• Aged < 18 years
• Trigeminal neuralgia, cluster headache, or other primary headache disorders as dominant diagnosis
• Not able to provide informed consent
• Known allergy/hypersensitivity to lidocaine or amide anesthetics
• Pregnancy/lactation
• Inability to tolerate intranasal nasal cotton pledgets
• Significant nasal pathology at placement site

Where it is running

• University Otolaryngology — East Providence, Rhode Island, United States (enrolling)

Full record on ClinicalTrials.gov

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