Adherence to Enteral Nutrition

Recruiting now

Conditions studied: Enteral Nutrition

In brief

Malnutrition is a major challenge in cancer nutrition, affecting approximately 40% of cancer patients and having negative consequences on treatment efficacy, quality of life, and prognosis. It must be detected and managed early, based on clinical and laboratory criteria defined by the HAS recommendations. To address this, several nutritional strategies are available, ranging from fortified oral feeding to artificial nutrition. Enteral nutrition, which is more physiological and carries fewer risks than parenteral nutrition, is recommended as the first-line treatment. Tools such as personalized care plans and guidelines help tailor patient care. However, enteral nutrition remains underutilized in clinical practice, despite the recommendations. The ADHENUTE study, conducted at the Institut Curie, showed low compliance with recommendations (31%) and a tendency to favor oral nutritional supplements, even in severely malnourished patients. The lack of traceability of decisions makes it difficult to identify barriers, although patient refusal is sometimes mentioned. To improve this situation, corrective measures have been implemented: * for patients, through educational workshops to help them better understand and accept enteral nutrition; * for healthcare providers, through training sessions to address reservations and enhance knowledge. A third phase of the study aims to evaluate the impact of these actions, with the goal of increasing adherence to recommendations and the use of enteral nutrition.

Key facts

Study ID

NCT07571564

Run by

Institut Curie

People needed

80

Starts

2026-03-05

Expected to finish

2027-09-04

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients hospitalized (including those in the day hospital) in a medical oncology unit;
• Adults;
• Men or women;
• Patients for whom enteral nutrition is indicated according to SFNCM recommendations;

You may not qualify if…

• Minors (under 18 years of age)
• Patients receiving end-of-life palliative care
• Individuals deprived of their liberty or under legal guardianship (including conservatorship);
• Adults under judicial protection;
• Inability to participate in the study for geographical, social, or psychological reasons.
• Persons referred to in Articles L. 1121-5 through L. 1121-8 and L. 1122-1-2 of the Public Health Code (e.g., minors, adults under guardianship, etc.).
• Patients who do not speak or understand French.

Where it is running

• Institut Curie — Paris, France (enrolling)

Full record on ClinicalTrials.gov

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