CoreSys Monitoring for Intraoperative Stress Management in Abdominal Hysterectomy

Recruiting now · Not applicable

Conditions studied: Surgical Stress Response, Inflammation, Anesthesia, Perioperative Care

In brief

This randomized controlled trial evaluates whether intraoperative guidance using the CoreSys monitor reduces the surgical stress response in patients undergoing elective open abdominal hysterectomy. Surgical stress involves complex hemodynamic, endocrine, and inflammatory responses that may negatively impact postoperative recovery. Patients will be randomized to either anesthesia guided by conventional clinical and hemodynamic parameters or anesthesia additionally guided by CoreSys-derived indices of consciousness, nociception, and stress activity. The primary objective is to assess whether CoreSys-guided anesthesia attenuates stress biomarkers, including interleukin-6 (IL-6), cortisol and glycemia.

Key facts

Study ID

NCT07571473

Run by

Hospital Provincial de Rosario

People needed

30

Starts

2025-01-08

Expected to finish

2026-05-30

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older, up to 70. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients aged 18-70 years
• Scheduled elective open abdominal hysterectomy in the morning
• Written informed consent

You may not qualify if…

• Refusal to participate
• Significant endocrine/metabolic disease
• Pacemaker or major arrhythmias
• Contraindication to epidural anesthesia

Where it is running

• Hospital Provincial de Rosario — Rosario, Santa Fe Province, Argentina (enrolling)

Full record on ClinicalTrials.gov

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