Upper Punctal Plug Occlusion in Previous Lower Punctal Occlusion.

Recruiting now · Not applicable

Conditions studied: DED, Aqueous-deficient Dry Eye Disease

In brief

This study evaluates the therapeutic effect of upper punctal plug occlusion in patients with dry eye disease with previous lower punctal occlusion.

Key facts

Study ID

NCT07571330

Run by

Universidad Autonoma de Nuevo Leon

People needed

36

Starts

2026-02-12

Expected to finish

2026-11-01

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients of both sexes
• One or both eyes may be included
• Inferior lacrimal punctum occluded (with a punctal plug or cauterization), clinically sealed under slit-lamp examination
• Functional superior lacrimal punctum
• Aqueous-deficient dry eye (such as Sjögren's disease, graft-versus-host disease, or primary dry eye disease.)
• Age >18 years
• OSDI score >13 and one of the following signs: Tear film markers (Fluorescein tear break up-time <5, First non-invasive tear breakup time <10, Schirmer test without anesthesia <10 mm, Schirmer test with anesthesia <10 mm), Ocular surface markers (corneal staining >5 spots or conjunctival staining >9 spots).

You may not qualify if…

• Active ocular surface infection.
• Patients who are unwilling to participate or to provide written informed consent.

Where it is running

• Ophthalmology Department — Monterrey, Nuevo León, Mexico (enrolling)

Full record on ClinicalTrials.gov

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