Letermovir vs Valganciclovir in CMV R+ Kidney Transplant

Starting soon · Phase 4

Conditions studied: CMV Infection, CMV, CMV Viremia, CMV Disease

In brief

The purpose of this study is to find out whether letermovir can help prevent cytomegalovirus (CMV) infection in kidney transplant recipients who are CMV seropositive. To do this, researchers will compare patients who received letermovir with a group of historical patients who received valganciclovir ("mini dose"). Both groups will be on CMV prophylaxis drug for 90 days post-transplant. The main question the study wants to answer is: • Does letermovir work as well as valganciclovir in preventing CMV infections during the first 12 months after a kidney transplant? The study will also look at other important questions: * Is letermovir easier for patients to tolerate than valganciclovir? * How long does it take for a CMV infection to appear in each group? * Are there differences in "breakthrough" CMV infections between the two medications? * For patients who develop CMV that becomes resistant to treatment, are the resistance patterns different between the two groups

Key facts

Study ID
NCT07571135
Run by
Elisabeth Kincaide
People needed
300
Starts
2026-05-01
Expected to finish
2028-11-01
Last updated by the study team
2026-05-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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