AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Obesity, Overweight, Obstructive Sleep Apnoea
In brief
This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with overweight or obesity, and obstructive sleep apnoea treated with positive airway pressure. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.
Key facts
- Study ID
- NCT07571109
- Run by
- Novo Nordisk A/S
- People needed
- 300
- Starts
- 2026-05-05
- Expected to finish
- 2028-08-21
- Last updated by the study team
- 2026-08-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Siteworks GmbH Bochum — Bochum, Germany (enrolling)
- Essence MD Research — Naples, Florida, United States (enrolling)
- Palm Beach Research Center — West Palm Beach, Florida, United States (enrolling)
- Dignity Health, Mercy Gilbert — Gilbert, Arizona, United States (enrolling)
- Physicians Research Associates — Lawrenceville, Georgia, United States (enrolling)
- Chicago Research Center, Inc — Chicago, Illinois, United States (enrolling)
- Weil Cornell Medicine — New York, New York, United States (enrolling)
- Lillestol Research LLC — Fargo, North Dakota, United States (enrolling)
- CTI Clinical Research Center — Cincinnati, Ohio, United States (enrolling)
- DM Clinical — Bradenton, Florida, United States (enrolling)
- Bogan Sleep Consultants, LLC — Columbia, South Carolina, United States (enrolling)
- Epic Medical Research — DeSoto, Texas, United States (enrolling)
- Advanced Neurology Epilepsy and Sleep Center ANESC — El Paso, Texas, United States (enrolling)
- Biorhythms Center for Integrative Sleep Medicine — El Paso, Texas, United States (enrolling)
- Houston Pulm Med Res Network — Houston, Texas, United States (enrolling)
- Sleep Therapy Research Center — San Antonio, Texas, United States (enrolling)
- Tricoastal Sleep Center — Sugar Land, Texas, United States (enrolling)
- Rainier Clin Res Ctr Inc — Renton, Washington, United States (enrolling)
- Seattle Clinical Research Center — Seattle, Washington, United States (enrolling)
- Woolcock Institute — Macquarie Park, New South Wales, Australia (enrolling)
- University of Sunshine Coast - Vitality Village — Birtinya, Queensland, Australia (enrolling)
- NeuroTrials Research, Inc. — Atlanta, Georgia, United States (enrolling)
- Nightingale Research Adelaide — Adelaide, South Australia, Australia (enrolling)
- University of Western Australia - Centre for Sleep Science — Crawley, Western Australia, Australia (enrolling)
- Wendisch - Dahl Hamburg - DZHW — Hamburg, Germany (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.