AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Obesity, Overweight, Obstructive Sleep Apnoea
In brief
This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with excess body weight and obstructive sleep apnoea not treated with positive airway pressure lose weight and improve sleep apnoea. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.
Key facts
- Study ID
- NCT07571005
- Run by
- Novo Nordisk A/S
- People needed
- 300
- Starts
- 2026-05-05
- Expected to finish
- 2028-10-04
- Last updated by the study team
- 2026-07-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Siteworks GmbH Bochum — Bochum, Germany (enrolling)
- Siteworks GmbH Hannover — Hanover, Germany (enrolling)
- Renstar Medical Research — Ocala, Florida, United States (enrolling)
- Sjællands Universitetshospital, Køge - Øre-Næse-Hals afdeling — Køge, Denmark (enrolling)
- Wendisch - Dahl Hamburg - DZHW — Hamburg, Germany (enrolling)
- University Of Chicago — Chicago, Illinois, United States (enrolling)
- Weil Cornell Medicine — New York, New York, United States (enrolling)
- CTI Clinical Research Center — Cincinnati, Ohio, United States (enrolling)
- PharmaDev Clinical Research Institute LLC — Miami, Florida, United States (enrolling)
- Regionshospitalet Gødstrup, Øre-næse-hals-kirurgisk — Herning, Denmark (enrolling)
- Artemis Insitute for Clin Res — San Diego, California, United States (enrolling)
- Biorhythms Center for Integrative Sleep Medicine — El Paso, Texas, United States (enrolling)
- Houston Pulmonary Medicine Associates, PA and Research Physicians Network, LLC — Houston, Texas, United States (enrolling)
- Sleep Therapy Research Center — San Antonio, Texas, United States (enrolling)
- Tricoastal Sleep Center — Sugar Land, Texas, United States (enrolling)
- Rainier Clin Res Ctr Inc — Renton, Washington, United States (enrolling)
- Woolcock Institute — Macquarie Park, New South Wales, Australia (enrolling)
- University of Sunshine Coast - Vitality Village — Birtinya, Queensland, Australia (enrolling)
- Conquest Research — Atlanta, Georgia, United States (enrolling)
- Nightingale Research — Adelaide, South Australia, Australia (enrolling)
- University of Western Australia - Centre for Sleep Science — Crawley, Western Australia, Australia (enrolling)
- Epic Medical Research — DeSoto, Texas, United States (enrolling)
- Advanced Neurology Epilepsy and Sleep Center ANESC — El Paso, Texas, United States (enrolling)
- Physicians Research Associates — Lawrenceville, Georgia, United States (enrolling)
- Siteworks GmbH Karlsruhe — Karlsruhe, Germany (enrolling)
Full record on ClinicalTrials.gov
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