IMPACT OF DIALYSIS DURATION AND DIURESIS ON BLADDER CAPACITY AND COMPLIANCE IN END STAGE RENAL DISEASE PATIENTS AWAITING RENAL TRANSPLANT

Recruiting now

Conditions studied: End-Stage Renal Disease Requiring Haemodialysis, Bladder Dysfunction

In brief

Patients with end-stage renal disease (ESRD) who are on dialysis for a long time may experience bladder problems as their urine output decreases and normal bladder filling is lacking. As a result, bladder capacity may be reduced and compliance may deteriorate, which can impact the success of kidney transplantation. Our prospective observational study is designed to investigate how dialysis duration and residual urine output (diuresis) influence bladder capacity and compliance in ESRD patients who are waiting for kidney transplantation. The adult patients undergoing regular dialysis will be assessed clinically, and they will also be subjected to laboratory tests, imaging, and urodynamic studies. Through this study, we aim to determine the frequency of bladder malfunction and its correlation with the length of dialysis and the amount of urine excretion. The results might enhance the pre-transplant workup and offer a basis for urological post-transplantation management that could minimize complications.

Key facts

Study ID

NCT07570771

Run by

Sindh Institute of Urology and Transplantation

People needed

87

Starts

2026-02-02

Expected to finish

2027-02-01

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged 18-65 years diagnosed with end-stage renal disease (ESRD)
• Patients on maintenance dialysis for a duration of 6 to 24 months
• ESRD secondary to non-urological causes
• Patients awaiting renal transplantation

You may not qualify if…

• Patients with diabetes mellitus
• Patients with neurogenic bladder
• Patients with prior urological surgeries
• Patients with active urinary tract infection
• Patients with pre-existing lower urinary tract symptoms before dialysis
• Patients on medications affecting lower urinary tract function
• Patients with neurological or systemic diseases affecting bladder function

Where it is running

• Sindh Institute of Urology and Transplantation (SIUT) — Karachi, Sindh, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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