Biomarkers of ASD/ADHD and Factors Affecting Anxiety and Depression in Children and Young Adults

Starting soon

Conditions studied: ADHD - Attention Deficit Disorder With Hyperactivity, Autism Spectrum Disorder (ASD), Developmental Coordination Disorder (DCD)

In brief

The PUREMIND OS1/OS2 study is a multinational, prospective, longitudinal observational study designed to identify early neurophysiological, biological, environmental, and psychosocial markers associated with neurodevelopmental and mental health conditions from infancy through young adulthood. Observational Study 1 (OS1) follows infants and toddlers at high risk for Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) to discover biomarkers predictive of later clinical diagnosis, using EEG, fNIRS, psychometric assessments, and biological samples. Observational Study 2 (OS2) includes children, adolescents, and young adults with ASD, ADHD, or Developmental Coordination Disorder (DCD) to identify environmental and biological factors causally linked to anxiety and depression symptoms, and to support the development of personalised criteria for evidence-based interventions. Approximately 800 participants will be recruited across 10 international clinical sites. The study aims to generate multi-domain data to support predictive modelling and inform future personalised mental-health prevention strategies across childhood and young adulthood.

Key facts

Study ID
NCT07570381
Run by
University of Exeter
People needed
800
Starts
2026-08-01
Expected to finish
2028-12-31
Last updated by the study team
2026-05-06

Who can join

Age: 1 and older, up to 25. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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