Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome

Recruiting now · Not applicable

Conditions studied: Arginine Vasopressin Deficiency, Primary Polydipsia

In brief

The aim of this study is to evaluate whether a new test using mannitol infusion can diagnose the cause of polyuria-polydipsia syndrome as accurately as the current standard test (hypertonic saline infusion) and to compare which test patients prefer. The goal is to identify a simpler and more patient-friendly diagnostic approach.

Key facts

Study ID

NCT07569861

Run by

University Hospital, Basel, Switzerland

People needed

144

Starts

2026-06-16

Expected to finish

2030-06-01

Last updated by the study team

2026-06-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Hypotonic polyuria/polydipsia syndrome defined as polyuria >40ml/kg body weight/24h and polydipsia >3l/24h; and urine osmolality <800mOsm/L or known AVP-D based on accepted criteria

You may not qualify if…

• Polyuria/polydipsia secondary to diabetes mellitus, hypercalcemia, or hypokalemia
• Diagnosis of AVP-R (Copeptin > 21.4 pmol/L)
• Evidence of acute illness
• Epilepsy requiring treatment
• Uncontrolled arterial hypertension (blood pressure >160/100mmHg at baseline
• eGFR < 60 ml/min/1,73 m2
• Cardiac failure (NYHA III-IV)
• Diagnosis of liver cirrhosis, Child-Pugh Class C
• Uncorrected adrenal or thyroidal deficiency
• Pregnancy or breastfeeding
• Current or unresolved urinary obstruction
• Enrollment in a clinical trial within the last 30 days
• Patients refusing or unable to give written informed consent
• Inability to follow study procedures

Where it is running

• University Hospital Basel — Basel, Switzerland (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.