Evaluation of the Stress Response in Anesthesia Use Inhalation Anesthetic (Desflurane) Versus TIVA for Bariatric Surgery
Recruiting now · Not applicable
Conditions studied: Opioid Use, Bariatric Surgery Candidate, TCI Eleveld, Obesity
In brief
The goal of this clinical trial is to compare the effects of Opioid Free Anesthesia (OFA) with and without volatile anesthetics (in this case desflurane) in patients undergoing bariatric surgery. The main question it aims to answer : -Will there be a difference in the perioperative stress between patients receiving OFA with and without desflurane? Participants will undergoing sleeve gastrectomy or gastric by pass, will be administered OFA with and without desflurane and blood tests (cortisole, ACTH,dopamine, PRL, adrenaline, noradrenaline, lactate) will be collected perioperatively to compare stress in the two groups.
Key facts
- Study ID
- NCT07568938
- Run by
- G.Gennimatas General Hospital
- People needed
- 70
- Starts
- 2024-01-10
- Expected to finish
- 2027-05-30
- Last updated by the study team
- 2026-05-06
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Signed Informed Consent
- ASA II-III
- Morbid obesity confirmed diagnosis and approval for surgical treatment
- Laparoscopic sleeve gastrectomy (LSG) or Gastric By pass (R-Y By pass /SASI/SADI AND one anastomosis by pass )
- Preop respiratrory assessment conducted
- Adequate organ and bone marrow function
You may not qualify if…
- Patients declining or withdrawing consent
- Patients unsuitabe with regards to compliance to treatment, according to the researcher's assessment
- Bradycardia, AV block, , postural hypotension
- QTcF>470msec
- Known allergy or hypersensitiity to any of the medications administered
- Stop-BANG score >6
- Intraoperative administration of more than 8mg of prednisolone or equivalent
- Patients who have received corticosteroids for durations >3 weeks at any point in their lifetime
- Participation in other clinical trial for experimental product administered post operatively
- Diagnosis of depression
Where it is running
- General Hospital of Athens G. Gennimatas — Athens, Greece (enrolling)
Full record on ClinicalTrials.gov
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