The Effect of Remifentanil on the Objectively Measured Pressure Pain Threshold

Enrolling by invitation · Not applicable

Conditions studied: Pain Threshold, Surgery, Postoperative Pain, Intravenous Anesthesia

In brief

It is a clinical study investigating the relationship between objectively measured pain threshold and the need for escalating doses of remifentanyl opioids. This study is expected to include approximately 40 participants. The aim of the study is to objectively measure the analgesic effect of an increasing dose of opioids just before anesthesia.

Key facts

Study ID

NCT07568405

Run by

Université Libre de Bruxelles

People needed

40

Starts

2026-01-26

Expected to finish

2026-06-15

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult patients who are able to volunteer
• ASA 1, 2and 3

You may not qualify if…

• Refusal to participate;
• Body mass index (BMI) > 30 kg/m²;
• Allergy to any medication used for anesthesia;
• Chronic pain or regular use of analgesics;
• Severe ventricular dysfunction, pulmonary hypertension, or uncontrolled arrhythmia;
• Non-elective surgery;
• Participation in another study within the last 3 months;
• Pregnancy or breastfeeding;
• Severe renal or hepatic impairment

Where it is running

• HUB Erasme — Brussels, Brussels Capital, Belgium

Full record on ClinicalTrials.gov

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