Tolerance to an Artisanal Bread in a Population Intolerant of the Conventional Bread and Study of Associated Markers
Recruiting now · Not applicable
Conditions studied: Intolerance to "Conventional" Bread
In brief
The objective of this study is to evaluate the effect of consuming an "artisanal" bread for 15 days on gastrointestinal symptoms in individuals intolerant to "conventional" bread. "Conventional bread" refers to bread made with refined wheat flour (ash = 0.55% of dry matter), containing gluten, and leavened with baker's yeast (Saccharomyces cerevisiae). "Artisanal bread" refers to bread made with whole wheat flour (ash = 1.50% of dry matter) from an ancient durum wheat variety (Russello) and leavened with sourdough.
Key facts
- Study ID
- NCT07568223
- Run by
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
- People needed
- 40
- Starts
- 2026-01-28
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-05-05
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Normal weight (18 < BMI < 25 kg.m-2)
- Male or female
- 18 to 65 years old
- Adults reporting intolerance to "conventional" bread
- Absence of celiac disease
- Affiliated to a social security scheme
- Free, informed and express consent
You may not qualify if…
- People under protective supervision: legal guardianship, tutorship or curatorship
- People with eating disorders (anorexia, bulimia, binge eating)
- Any known food allergy
- Women who are pregnant or potentially pregnant (based on a positive urine pregnancy test at inclusion)
- Breastfeeding women
- Alcohol abuse (>2 drinks/day). At the time of inclusion, the investigator will assess whether the participant exhibits harmful alcohol consumption
- Untreated hypertension, uncontrolled diabetes, or diseases of the digestive tract (excluding functional intestinal disorders), liver, kidneys, or severe heart disease. The investigator will assess the presence of these conditions on standard clinical criteria and the participants' self-reported medical history at the time of inclusion
- Participation in a clinical study in the three months preceding the study
- Absence of express consent
Where it is running
- Centre de Recherche sur Volontaires — Bobigny, France (enrolling)
- Centre de Recherche sur Volontaires (CRV) — Bobigny, Île-de-France Region, France
Full record on ClinicalTrials.gov
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