Taurine for the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma
Starting soon · Phase 2
Conditions studied: Oral Mucositis (Ulcerative) Due to Radiation, Nasopharyngeal Carcinoma (NPC)
In brief
This clinical trial aims to understand whether taurine can prevent and reduce severe radiation-induced oral mucositis in patients with nasopharyngeal carcinoma undergoing radiotherapy.
Key facts
- Study ID
- NCT07567742
- Run by
- Sun Yat-sen University
- People needed
- 130
- Starts
- 2026-05-06
- Expected to finish
- 2029-03-30
- Last updated by the study team
- 2026-05-05
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-70 years.
- Histologically confirmed newly diagnosed non-keratinizing nasopharyngeal carcinoma (WHO classification).
- Non-metastatic nasopharyngeal carcinoma (Stage I-III) according to the AJCC 9th edition staging system.
- Scheduled to receive radical intensity-modulated radiotherapy (IMRT).
- No prior history of anti-cancer treatment.
- ECOG performance status 0-1; adequate organ function within 2 weeks before enrollment; Hematology: hemoglobin > 90 g/L; absolute neutrophil count > 1.5×10⁹/L; platelet count > 100×10⁹/L. Biochemistry: total bilirubin ≤ 1.5×ULN; ALT, AST ≤ 2.5×ULN; ALP ≤ 2.5×ULN; creatinine clearance ≥ 50 mL/min.
- For patients with abnormal ECG or prior cardiovascular disease, additional cardiac function tests and echocardiography must be normal.
- Provided written informed consent and willing to comply with study visits, treatment, laboratory tests, and other protocol requirements.
You may not qualify if…
- Known intolerance or hypersensitivity to taurine or its excipients.
- Conditions that interfere with oral drug administration (e.g., dysphagia, chronic diarrhea, intestinal obstruction).
- Prior history of malignant tumor.
- Pregnant or lactating women. (Pregnancy testing is required for women of childbearing potential; effective contraception must be used during treatment.)
- History or presence of severe oral ulcers, oral diseases, or salivary gland diseases.
- Unwilling to stop smoking, drinking alcohol, or chewing betel nut.
- Presence of severe active comorbidities.
- Severe dysfunction of heart, brain, lung, or other vital organs.
- Active infection requiring treatment; long-term use of immunosuppressive agents; psychiatric disorders.
- Unable to complete radiotherapy or likely to delay radiotherapy for more than 1 week due to subjective factors.
- Any other condition deemed inappropriate by the investigator.
Where it is running
- Sun Yat-sen University Cancer Center — Guangzhou, Guangdong, China
Full record on ClinicalTrials.gov
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