Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery

Starting soon · Phase 4

Conditions studied: Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids, Spinal Anesthesia for Cesarean Section, Dexmedetomidine, Clonidine, Postoperative Analgesia

In brief

This study will examine whether addition of dexmedetomidine or clonidine (two alpha-2 adrenergic agonists) will improve the comfort of patients during spinal anesthesia for cesarean delivery. When added to standard spinal anesthesia consisting of bupivacaine (a local anesthetic) and fentanyl and morphine (two opioids), these medications may decrease some of the pulling/tugging/pressure sensations that patients sometimes feel during cesarean delivery, may prolong the anesthetic time, and may decrease postoperative pain.

Key facts

Study ID

NCT07567495

Run by

Columbia University

People needed

150

Starts

2026-06-01

Expected to finish

2028-05-01

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Pregnant women undergoing cesarean delivery with spinal anesthesia

You may not qualify if…

• Significant cardiovascular, psychiatric or respiratory disease
• using opioids or with chronic pain syndrome
• Multiple gestation
• BMI >40 kg/m2
• Quaternary or greater cesarean
• < 37 weeks gestation
• Non-English or Spanish speaking
• planned vertical skin incision
• planned vertical (classical) uterine incision
• allergy to clonidine, dexmedetomidine or other study drug

Where it is running

• Columbia University Irving Medical Center/NewYork Presbyterian Hospital — New York, New York, United States

Full record on ClinicalTrials.gov

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