The Finnish Uterine Prolapse Surgery Trial (The Fin-UP Trial)

Recruiting now · Not applicable

Conditions studied: Uterine Prolapse, Pelvic Organ Prolapse Vaginal Surgery, Pelvic Organ Prolapse (POP)

In brief

The goal of this clinical trial is to compare the Manchester procedure and vaginal hysterectomy in treating patients with symptomatic uterine prolapse. The main question it aims to answer is: • What is the difference in the success rates at the the two year follow-up Participants will: * be randomized in either the Manchester procedure or vaginal hysterectomy group and operated as such * visit the clinic at 2 and 5 years after the operation * fill in questionnaires at 1, 2, 5 and 10 years after the operation

Key facts

Study ID

NCT07566949

Run by

Tampere University Hospital

People needed

426

Starts

2026-05-01

Expected to finish

2041-12-01

Last updated by the study team

2026-05-11

Who can join

Age: 18 and older, up to 100. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Fit for elective vaginal surgery according to standard preoperative assessment
• Women aged over 18 years
• No previous POP surgery
• Symptomatic POP stage 2 or higher, with uterine descent of at least stage 2 (POP-Q point C ≥ minus 1) and with POP-Q point D ≤ minus 1. Patients with concurrent anterior or posterior compartment defects will be included.

You may not qualify if…

• Pregnancy or future plans of pregnancy
• Active malignancy of any kind
• Contraindications for uterine preservation, i.e. suspected cervical or uterine malignancy, abnormal cervical cytology, abnormal uterine bleeding, a history of endometrial hyperplasia with atypia, or a known hereditary cancer syndrome involving the uterus (e.g., Lynch syndrome). All patients will undergo a clinical examination and ultrasound assessment prior to recruitment. If clinically indicated, a Pap-smear and/or endometrial biopsy will be performed prior to inclusion.
• Contraindication to vaginal hysterectomy (e.g. extensive intra-abdominal adhesions)
• Patient's preference for uterine removal or preservation
• Planned concomitant incontinence procedure
• Inability to speak Finnish or Swedish, understand the purpose of the study, or commit to follow-up

Where it is running

• Helsinki University Hospital — Helsinki, Finland (enrolling)
• Hospital Nova, The Wellbeing Services County of Central Finland — Jyväskylä, Finland (enrolling)
• Kuopio University Hospital — Kuopio, Finland (enrolling)
• Oulu University Hospital — Oulu, Finland (enrolling)
• Tampere University Hospital — Tampere, Finland (enrolling)
• Turku University Hospital — Turku, Finland (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.