A Phase II Trial Evaluating Upfront Stereotactic Body Radiotherapy in Stage III Advanced Non-small Cell Lung Cancer

Recruiting now · Not applicable

Conditions studied: Non Small Cell Lung Cancer

In brief

The aim of the study is to test the feasibility \& loco-regional control rate by combining high precision SBRT with chemotherapy in stage III NSCLC in tumor/lymph nodes if tumors/lymph node size with ≤ 6cms in size.

Key facts

Study ID

NCT07565987

Run by

All India Institute of Medical Sciences

People needed

20

Starts

2023-02-01

Expected to finish

2027-01-30

Last updated by the study team

2026-05-04

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Aged 18 or above and less than 75 years.
• Histologically proven non-small cell lung cancer.
• Stage T1-4, N1-3, M0 with maximum tumor size less than 6 cms and ≤ 3 stations of largest lymph node size less than 4 cms.
• ECOG status 0-1.
• Available to attend long term follow- up.
• Written informed consent for treatment.

You may not qualify if…

• Metastatic disease.
• Tumor size > 6cm.
• Involved Lymph node size greater than 4 cms \& more than 3 station of lymph nodes involved.
• Patients with superior vena cava obstruction.
• Tumor invading/encasing the proximal bronchial tree/, esophagus, pericardium.
• Previous radiotherapy to thorax.
• Small cell histology.
• Age< 18 or > 75 years.
• Patients on anticoagulant therapy \& ultra-central cavitary tumors.
• Poor performance status ECOG 2-3.
• Immunocompromised states.
• Viral Markers negative.
• Pregnant women

Where it is running

• Nci, Aiims-Jhajjar — Jhajjar, Haryana, India (enrolling)

Full record on ClinicalTrials.gov

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