Group Retreat Psilocybin Therapy for Healthcare Clinicians With Loss of Meaning in Their Work and Symptoms of Depression

Starting soon · Phase 2

Conditions studied: Depression, Anxiety

In brief

In this single-arm Phase 2 study, the researchers are assessing the feasibility of the group retreat format for clinicians and explores different 'doses' of preparation. A sequential dose-escalation design is used. The study will recruit healthcare clinicians (physicians, nurses, nurse practitioners, physician assistants) aged 25-70 years currently in clinical practice with moderate or greater symptoms of depression and loss of meaning during the past 5 years. Each participant will be in a group cohort of 8, and 3 cohorts will be tested at each dose level. The objectives are safety, feasibility, mechanism testing, and outcomes.

Key facts

Study ID

NCT07565909

Run by

University of Washington

People needed

72

Starts

2026-06-01

Expected to finish

2028-07-01

Last updated by the study team

2026-05-04

Who can join

Age: 25 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Healthcare clinicians (physicians, nurses, nurse practitioners, physician assistants) currently in clinical practice
• Age 25-70 years
• Loss of meaning single question "I used to find deep meaning in my work as a healthcare clinician, but during the past 5 years that sense of meaning has faded".
• PHQ-9 score ≥10 (moderate symptoms of depression)
• Ability to commit to all preparation sessions and retreat attendance
• English fluency sufficient for group participation
• Screening laboratory tests within acceptable limits, including liver function tests
• Negative urine drug screen for non-prescribed psychoactive medications.
• ECG with QTc <450 ms
• Willing to taper and discontinue any supplements with serotonin-like properties, including but not limited to 5-HTP, St. John's Wort, and 'brain food' supplements.
• For participants of childbearing potential, agree to use to use highly effective contraception. Highly effective contraceptive methods are defined as those that, alone or in combination, result in a low failure rate (less than 1 percent per year), including but not limited to implants, IUDs, contraceptive injections, or contraceptive pills.

You may not qualify if…

• Personal or first-degree family history of psychotic disorder or bipolar I disorder
• Personal major depressive episode prior to entering healthcare as a professional
• Active suicidal ideation with intent or plan
• Unstable medical conditions
• Pregnancy or breastfeeding
• Hypertension with BP systolic >150 or diastolic > 90

Full record on ClinicalTrials.gov

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