A Study to Understand the Analgesic Properties of Topically Applied Menthol When Used in a Marathon.

Completed

Conditions studied: Muscle Soreness

In brief

The purpose of the research study is to gather the opinions and/or perceptions relating to the use of topically applied menthol and experience of pain during and after a marathon in adult runners (18+ years) participating in the 2025 Chicago Marathon. The main questions it aims to answer are: * Does topically applied menthol reduce pain levels in marathon runners during recovery? * How quickly does pain relief occur after topically applied menthol application? * What are the sensory attributes (e.g., cooling sensation) associated with topically applied menthol use during and after the race? * How do demographic factors (e.g., age, sex, menstrual cycle stage, sleep quality) influence pain experience and topically applied menthol effectiveness? Researchers will compare pre- and post-application pain scores in the Recovery Application Zone to see if Biofreeze provides measurable pain relief and sensory benefits. Participants will: * Provide documented informed consent prior to participation. * Self-select to use Biofreeze products during or after the race. * Complete one or both of the following: 1. Recovery Application Zone Questionnaire (includes pain score before and after Biofreeze application, sensory assessments, demographics). 2. End of Race Questionnaire (includes retrospective recall of pain relief, product use, sensory experience, and demographic data).

Key facts

Study ID

NCT07565246

Run by

Reckitt Benckiser Healthcare (UK) Limited

People needed

367

Starts

2025-10-12

Expected to finish

2025-10-12

Last updated by the study team

2026-05-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participant has provided documented informed consent.
• Participant aged 18 years and above.
• Participant is entrant into the Chicago marathon 2025.
• Participant has self-selected to use topically applied menthol during the race or during immediate recovery.
• Comprehension of and able to read English.

You may not qualify if…

• Employee of Sponsor or Agency/ vendor collecting the data

Where it is running

• Curion Strategic Product Insights — Deerfield, Illinois, United States

Full record on ClinicalTrials.gov

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