Effect of aiTBS on Intrinsic Spectral Dynamics and Task Performance

Starting soon · Not applicable

Conditions studied: Brain Plasticity

In brief

Aim 1: Measure local shifts in cortical spectral dynamics following aiTBS. Aim 2: Measure network-specific shifts in task performance following aiTBS. Exploratory aim: Evaluate changes to resting state spectral dynamics in absence of stimulation after aiTBS.

Key facts

Study ID

NCT07565207

Run by

University of Pennsylvania

People needed

80

Starts

2026-10-01

Expected to finish

2030-05-30

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Able to give their consent
• Right-handed or ambidextrous

You may not qualify if…

• Non-english speaking
• Current or past non-anxiety-related psychiatric comorbidity.
• Active or history of active suicidal ideation
• Alcohol/drug problems in the past year or lifetime alcohol or drug dependence
• Medications that act on the central nervous system
• History of seizure
• History of epilepsy
• Increased risk of seizure for any reason
• Pregnancy, or positive pregnancy test
• Any medical (e.g., stroke, breathing problems, motion disorders) or neurological (e.g., a significant brain injury or brain infection history that increases seizure risk) condition that increases risk for fMRI or TMS (Protocol will follow recommendations from Rossi et al. 2021 doi:10.1016/j.clinph.2020.10.003)
• Any metal in their body which would make having an MRI scan unsafe
• Any sort of medical implants
• Hearing loss
• Claustrophobia
• orthostatic hypotension

Full record on ClinicalTrials.gov

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