Ultrasound-Guided Dextrose Prolotherapy for Coccydynia: A Prospective Study

Recruiting now · Not applicable

Conditions studied: Coccydynia

In brief

Coccydynia is a musculoskeletal condition characterized by pain in the coccygeal region, particularly exacerbated by sitting, and is associated with impaired quality of life and functional limitation. Although various conservative and interventional treatment options are available, there remains a need for effective and safe alternative therapies, especially in treatment-resistant cases. Prolotherapy is a regenerative treatment modality that aims to reduce pain and improve function by stimulating tissue repair, particularly in ligamentous structures. While there is increasing evidence supporting its effectiveness in mechanical musculoskeletal pain conditions, the literature regarding its use in coccydynia is limited. The aim of this study is to evaluate the effect of dextrose prolotherapy on pain severity and functional status in patients diagnosed with coccydynia. This study is designed as a prospective, single-arm, open-label interventional study. Patients will receive 15% dextrose prolotherapy according to a standardized protocol. Pain severity will be assessed using the Visual Analog Scale (VAS), and functional status will be evaluated using the Dallas Pain Questionnaire before treatment and at 1 month after completion of the treatment. This study aims to provide more comprehensive data on the effectiveness and safety of prolotherapy in coccydynia and to contribute to the currently limited evidence in the literature.

Key facts

Study ID

NCT07564167

Run by

Gaziosmanpasa Research and Education Hospital

People needed

30

Starts

2026-01-15

Expected to finish

2026-06-15

Last updated by the study team

2026-05-04

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 18 and 75 years
• Pain persisting for ≥3 months and refractory to conservative treatment
• Coccydynia of mechanical or idiopathic origin

You may not qualify if…

• Age <18 years or >75 years
• Pregnancy
• Allergy to the proliferant solution
• Active infection
• Use of anticoagulant medications
• Presence of malignancy
• Local abscess
• Hemorrhagic diathesis
• Certain types of septic arthritis
• Parafunctional habits

Where it is running

• Gaziosmanpasa Research and Education Hospital — Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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