One Versus Five Days of Antibiotics After Appendectomy
Starting soon · Not applicable
Conditions studied: Post Operative Antibiotic Therapy of Acute Appendicitis
In brief
The goal of this clinical trial is to learn if a one-day course of antibiotics after appendectomy surgery works as well as a five-day course to prevent infections in children and adults (aged 10 years and older) with uncomplicated acute appendicitis (non-ruptured, non-gangrenous appendix). The main questions it aims to answer are: * Does a one-day antibiotic regimen result in a similar rate of surgical site infections, intra-abdominal abscesses, or death within 30 days after surgery compared to a five-day regimen? * What is the rate of hospital readmission, antibiotic-related side effects, and cost-effectiveness for each treatment duration? Researchers will compare participants receiving 24 hours of intravenous antibiotics to participants receiving 5 days of antibiotics (1 day intravenous followed by 4 days oral) to see if the shorter course is non-inferior (not meaningfully worse) to the longer standard course. Participants will: * Undergo appendectomy for uncomplicated acute appendicitis * Be randomly assigned to receive either one day or five days of postoperative antibiotics * Receive follow-up at 30 days after surgery, including a telephone call to check for infections, readmissions, or other complications * Allow study staff to collect information from their medical records regarding hospital stay, antibiotic side effects, and any need for reoperation or restarting antibiotics
Key facts
- Study ID
- NCT07563933
- Run by
- Ministry of Health and Population, Egypt
- People needed
- 200
- Starts
- 2026-05-01
- Expected to finish
- 2027-04-30
- Last updated by the study team
- 2026-05-04
Who can join
Age: 10 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged ≥10 years.
- Undergoing appendectomy with intraoperative diagnosis of straightforward acute appendicitis ( non-phlegmonous, non-gangrenous, non-perforated, no abscess).
You may not qualify if…
- Complex appendicitis (gangrenous, perforated, abscess).
- Severe sepsis at presentation.
- Immunocompromised state ( including diabetic patients ).
- Pregnancy.
- Allergy to study antibiotics.
- Concurrent infections requiring antibiotics.
Where it is running
- Fayoum General Hospital — Al Fayyum, Egypt
Full record on ClinicalTrials.gov
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