Vascular Aging and Microcirculation: Physiological Aspects of Vascular Aging in the Elderly Population (VAMP-Aging)

Starting soon

Conditions studied: Aging Problems

In brief

Rising life expectancy worldwide challenges public health due to increased cardiovascular disease linked to vascular aging, where microvascular dysfunction serves as an early indicator of system-wide inflammation, or "inflammaging". The proposed study aims to validate non-invasive, high-resolution techniques, such as Laser Speckle Contrast Imaging, to identify early endothelial senescence biomarkers and map their correlation with metabolic, inflammatory, and anthropometric profiles to advance personalized, preventive translational medicine.

Key facts

Study ID

NCT07563725

Run by

National Institute of Cardiology, Laranjeiras, Brazil

People needed

62

Starts

2026-06-01

Expected to finish

2029-12-01

Last updated by the study team

2026-05-04

Who can join

Age: 60 and older, up to 100. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Absence of symptoms and history of cardiovascular and cerebrovascular diseases.
• Baseline blood pressure levels within the normal range (< 140/90 mmHg, according to WHO criteria) and absence of use of antihypertensive medications.

You may not qualify if…

• Diabetes Mellitus: Fasting blood glucose ≥ 126 mg/dL or use of hypoglycemic agents.
• Smoking: Active or quit less than 5 years ago.
• Inflammatory Diseases: Autoimmune diseases, active neoplasms, or acute infectious processes.
• Surgery or trauma in the last 60 days.
• Renal Dysfunction: Chronic renal failure (estimated by eGFR < 60 mL/min/1.73m²).
• Medication Use: Chronic use of corticosteroids, immunosuppressants, or drugs with direct action on vascular reactivity (e.g., continuous use of nitrates).

Where it is running

• Eduardo Tibiriçá — Rio de Janeiro, Brazil

Full record on ClinicalTrials.gov

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